Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities

Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local and inflammatory responses. Several infectious diseases triggered their build up in the blood tissues. The mobilization of eosinophils into lungs is regulated by a cascade processes guided Th2 cytokine generating T-cells. Recruitment essentially leads to characteristic response followed airway hyperresponsiveness remodeling, which hallmarks chronic respiratory diseases. By analysing dynamic interactions extracellular environment, also involve signaling molecules tissues, various therapies have been invented developed target Having entered clinical testing, several eosinophil targeting therapeutic agents shown much promise further bridged gap between theory practice. Moreover, researchers now clearer understanding roles mechanisms eosinophils. These factors successfully assisted molecular biologists block specific pathways growth, migration activation primary purpose this review provide an overview biology special emphasis on potential pharmacotherapeutic targets. summarizes promising eosinophil-targeting agents, along rationale for use, including those developmental pipeline, trials, or approved other disorders.